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This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair

Substantial or rapid reduction in body weight can alter the hypothalamic-pituitary-ovarian (HPO) axis, leading to changes in oestrogen and progesterone levels

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