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NIH/NLM
Use ethyl chloride spray to numb the skin over the injection site
Due to the financial success of originator anti-TNFs, especially adalimumab, infliximab and etanercept, several industries have developed biosimilars of anti-TNFs during the past decade, according to strict requirements [175,176,177]
Room temperature is the documented storage condition, so travel at ambient temperature is acceptable as long as sustained heat exposure (hot car interiors, checked luggage in cargo holds during summer) is avoided
Nevertheless, combining with prescription meds or supplements is not recommended
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