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Carcinogenesis 31 , 804811 (2010)

At certain concentrations and time points, overstimulation may suppress rather than enhance melatonin output, highlighting the importance of dose, timing, and context when considering clinical protocols [1]

In the field of prescription medications, most medications that small uncontrolled studies have suggested may have some positive effects are later shown to not have significant positive outcomes after being tested in the much larger, more rigorous studies required to attain FDA approval