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As an example, LY3502970 showed a high bioavailability of 21% to 28% in cynomolgus monkeys

189 HSP90 also promotes the activation of oncogenic protein kinases such as JAK2/STAT3, PI3K/AKT, and MAPK, facilitating cancer progression

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The mechanism is not entirely clear, but B12 plays a role in nervous system function and neurotransmitter synthesis, which may help modulate the nausea response triggered by GLP-1 receptor activation in the brainstem