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Normal adjustment symptoms These are expected and typically manageable: loose stools 1 to 3 times daily during dose escalation, mild abdominal cramping before bowel movements, increased urgency (needing to go sooner than usual), softer stool consistency without other alarming features, symptoms that correlate with recent dose increases, and gradual improvement over 2 to 4 weeks at a stable dose

TrimRx explains that improvements in appetite and energy often show within weeks, which builds confidence early

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Events leading to discontinuation occurred in 13.2% of the semaglutide group and 11.9% of the placebo group, and 26% of participants overall permanently discontinued semaglutide or placebo

The post-medication opportunity Former GLP-1 users may represent one of the most important and underserved groups