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Current research, including data from the Womens Health Initiative (WHI), shows that risk varies based on: Type of therapy used Timing of treatment Personal health history The benefits of menopause hormone therapy may outweigh the risks if treatment is started before age 60 or within 10 years of menopause
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doi: 10.1016/j.jclinepi.2013.08.003 Summary Keywords adverse drug reaction, bupropion, depression, dose-dependent, Naranjo scale, oral GLP-1 receptor agonist, rechallenge, semaglutide Citation Alanazi AS and Alanazi BA (2026) Case Report: Oral semaglutide-associated depression in a patient with type 2 diabetes mellitus: a dose-dependent recurrence confirmed on rechallenge and managed with vortioxetinebupropion combination therapy
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