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In contrast to IR, IGF-1R is ubiquitously expressed in tissues in which it plays a role in tissue growth, mostly via the growth hormone, which liberates IGF-1 to activate the IGF-1R
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Its original characterisation used isolated amphibian and reptilian skin bioassays before the cloned human receptors were available, and those historic potency data remain the reason the compound is described as superpotent in the older literature
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