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Experimental evidence has demonstrated that Trx upregulation attenuates AGE-mediated neurodegeneration, potentially through TXNIP/mTOR axis suppression and subsequent autophagic inhibition (133)
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A previous study from our lab showed that primary lung fibroblasts isolated from aged mice have a senescent phenotype [18]
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Within the retromer complex, SNX proteins are primarily responsible for membrane remodeling and are thus essential for the vesicle budding and formation
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