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Many trials recruited participants with skin conditions or utilized intravenous administration routes, which fall outside our criteria for oral supplementation in healthy individuals

Weight loss may be slow: While some patients lose a few pounds of water weight or inflammation in the first few weeks, significant, rapid fat loss usually does not occur until you step up to higher therapeutic doses (such as 0.5 mg, 1.0 mg, or higher, depending on your doctors plan)

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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]