JAMA 282:15681575 Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
Does Oral Semaglutide Work for Weight Loss
Craig CM, Liu LF, Deacon CF, et al
Novo puts $285m into monthly GLP-1 based on Ascendis tech Novo Nordisk has partnered with Ascendis Pharma on less frequently dosed drugs for obesity and other metabolic diseases, starting with a once-monthly GLP-1 receptor agonist
We dont have a lot of human data with prolonged exposure, other than in the context of hypoglycemia, that people have looked at, he said, so it is not clear what other effects, either beneficial or adverse, the antagonists might have