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In early 2025, Pfizer scrapped its own experimental obesity pill (an oral GLP-1 candidate) due to safety concerns ( [35] ) ( [8] )

Unlike 6-OHDA-based models, generating the chronic oral rotenone model in mice does not require stereotaxic neurosurgical intervention

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Weight loss contributes in increasing the GLP-1 levels leading to improved glucose control in type 2 diabetes