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The most significant clinical evidence for retatrutide to date comes from a Phase 2 trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)
Aim for half your body weight in ounces of water daily as a baseline
Instead, they highlight predispositions in your peptide genetic pathways that should be interpreted alongside your clinical history, current biomarkers, and provider expertise
A higher proportion of the hormone therapy users achieved the weight loss that they were aiming for within one year
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