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These are standard limitations that apply to most telehealth outcome studies
A few possible relevant articles were excluded due to language issues
Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms
Similar overlaps may exist in atopic dermatitis, but additional Th2-mediated immune mechanisms could be involved, as in asthma [7, 8]
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