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Indeed, 84-B10 significantly alleviates cisplatin-induced acute kidney injury in mice [184]

Long-term side effects are less common but can be more significant

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Clinical trials show that people lose an average of 15-22% of their body weight over 68 weeks, but the timeline varies based on genetics, lifestyle, and individual metabolism

Tie et al, 2009), yet the significance of CBP/p300 (and H3K27ac) to NRF2 activity has not been explored for the broader NRF2 transcriptome