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While their main role remains in diabetes treatment, certain GLP-1 therapies are also approved for weight management in individuals with obesity or overweight with comorbidities, given their modest but clinically meaningful effects on appetite regulation and body weight 2 , 6 , 7

Diabetes (2014) 63(11):367485

For example, although nobiletin alleviates AKI in UUO mice by suppressing ferroptosis, it induces ferroptosis in melanoma cells through the GSK3-regulated Keap1/NRF2/HO-1 pathway [248, 306]

Patients have reported both positive and negative mood alterations

Looking ahead, the future of GLP-1s is brimming with possibilities