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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002
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doi: 10.1177/2053369114531909 12 CordtsEBChristofoliniDMSantosAADBiancoBBarbosaCP
The Lancet 368(9548):16961705 Popoviciu MS, Pduraru L, Yahya G, Metwally K, Cavalu S (2023) Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials
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