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The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

They are formed in the body from normal metabolism (such as converting food to energy), but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution

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