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We first examined the concentration-dependent effect of PFOS on mitochondrial bioenergetics and discovered that an increase in the PFOS concentration from 100 to 200 M significantly decreased mitochondrial bioenergetics, as evidenced by the decreased ATP production, maximal respiration and spare respiratory capacity, and increased proton leakage (Fig
Archived from the original on 22 February 2017
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Methods Cells, reagents Human PCa cell lines DU145 and 22Rv1 were from Cancer Research UK Laboratories (Clare Hall Hertfordshire UK) and Professor Sir Walter Bodmer (University of Oxford, UK) respectively
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