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Efficacy and safety of once weekly semaglutide 2.4 mg for weight management in a predominantly East Asian population with overweight or obesity (STEP 7): a double-blind, multicentre, randomised controlled trial

History & Research Background GHK was originally identified in human plasma and later studied in relation to age-associated changes, tissue-remodeling models, copper coordination, extracellular-matrix biology, and gene-expression patterns

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These factors lead to lipid peroxidation of the sperm membrane, decreased motility, and increased sperm DNA fragmentation, ultimately compromising fertilization capacity [9, 14]