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The primary reason is still sustainable weight change under medical supervision

Adequate fiber, hydration, and in some cases magnesium supplementation help manage this

If there are fewer restrictions with orforglipron, that would be appealing. The drug is expected to cost less than injectable options, Zerr says, and some patients may find it easier to take a pill every day than give themselves a weekly shot

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The reasons are multifaceted: rodent models of neurodegeneration imperfectly recapitulate human disease