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While higher doses generally lead to more weight loss, a dose thats too high for you can cause problematic side effects that affect your quality of life and ability to stick with treatment

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Weaknesses The lack of required baseline lab work is concerning from a medical safety perspective

Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated significant weight reduction in adults with obesity, and Phase 3 trials are ongoing (ClinicalTrials.gov)

A large population-based cohort study reported an approximately 3-fold increased risk of developing euDKA with SGLT2 inhibitor use versus other oral hypoglycemic agents [7]