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Conduct a literature search for published dose ranges in your specific animal model and species 2

Collectively, these translational challenges provide a rationale for investigating dual PDE1B/PDE10A inhibition, which has the potential to achieve broader modulation of dopaminergic circuits and to improve symptomatic outcomes at lower, potentially safer doses compared with single-target approaches

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Weeks 4-8: Noticeable improvements in body composition beyond what TRT alone was producing