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This head-to-head randomized trial directly compared tirzepatide with semaglutide for obesity treatment and provides high-level evidence for the magnitude of weight loss achievable with current incretin-based pharmacotherapy
N Engl J Med, 375:1834-1844
Cells 11, 1916
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Longer-term data have also shown that some participants following an intensive protocol lost an average of 26.6% of their body weight, or more than 60 pounds, over roughly two years
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