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BMJ (2015) 350:g7607
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand names Ozempic and Rybelsus) and chronic weight management (under the brand name Wegovy)
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Berberine, conversely, works primarily through AMPK activation and multiple downstream pathways
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