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As humans age, pineal gland calcification and declining melatonin production disrupt circadian rhythms, impair sleep quality, suppress immune function, and accelerate oxidative damage

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This might especially be the case at low rates of ascorbate oxidation, which will probably entail low accumulation of MDHA and low rates of DHA formation (Tuzet et al

Testing these hypotheses is an exciting direction, but further work needs to be completed