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Funding This work was supported by the National Natural Science Foundation of China (No
Novo Nordisk filed an NDA for the CagriSema combination in December 2025, with an FDA decision anticipated in late 2026
The 1,400-patient STEP UP trial found an average weight loss of 21% with Wegovy 7.2 mg, with more than a quarter (27%) of people treated with that dose falling into the early responder category, and discontinuation rates due to side effects were at the same level as the 2.4 mg dose
Appetite returns progressively across that window rather than all at once
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The most clinically significant effect on electrolyte balance stems from gastrointestinal adverse effects
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