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Combining Suboxone with oxycodone can cause serious side effects, including difficulty breathing, extreme drowsiness, and potential coma

J Pharmacol Exp Ther (2011) 339:50918.10.1124/jpet.111.185694 135 KawasLHMcCoyATYamamotoBJWrightJWHardingJW

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The trials were originally met with limited enthusiasm since several extensive outcome trials had indicated that intensified diabetes therapy was not associated with cardiovascular benefit