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44 During starvation, beta-cells adapt by markedly reducing their number of intracellular insulin vesicles via degradation, and these cells can rapidly replenish their insulin stores and return to a normal morphology in response to refeeding

While GLP-1 receptors are present in the kidneys and may have mild natriuretic effects, they do not typically cause clinically significant polyuria (excessive urination) in the way that diuretic medications do

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In states that permit automatic substitution of interchangeable biosimilars and where payers have erected formulary incentives for biosimilar use, the interchangeable product can capture market share faster and at higher volume than a non-interchangeable competitor that requires an explicit prescriber switch

Fatty infiltration of the pancreas promotes impaired pancreatic -cell function and gradual hyperglycemia, which will further enhance de novo hepatic lipogenesis and promote higher NEFAs levels to the circulation (the twin cycle hypothesis) [18]