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December 2017

2013 Oct 2;98(6):1514-23

In summary, the role of lactate in macrophages cannot be oversimplified as merely promoting M2. It functions more like a double-edged sword, with its ultimate effect, whether it favors pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes, being tightly regulated by factors such as concentration, duration, cell origin, and the overall tissue microenvironment [108]

Adaptogens and adrenal glandulars give many patients benefits along with the improvement of symptoms