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informatic analysis suggested robust elevated activation of the cysteine proteases Calpains 1 and/or 2 (Capn1/2) in both human and experimental NASH fibrosis (PMID: 36778394)

The structural alteration in APOE4 impairs its ability to bind and transport lipids (cholesterol, phospholipids) efficiently, compared to APOE3 and APOE2

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