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The anticaries effect of a food extract (shiitake) in a short-term clinical study
The -SH groups require re-oxidation to the disulfide (S-S) form to regenerate lipoate as a competent acetyl acceptor
At microdoses, the same mechanisms activate, just more gently
Front Mar Sci
More reliable detection reagents would facilitate both the basic study of this axis as well as clinical development--advances in antibody and peptide generation (such as those employed by the Institute for Protein Innovation) will hopefully be leveraged to improve sensitivity and specificity of clinical assays
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