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Nature 632 , 585593 (2024)
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Clinical trials of AOD-9604 lasting up to 24 weeks demonstrated no cardiovascular adverse events and excellent overall tolerability
A tumours metabolic requirements and their regulation can be changed upon cell adaptation to in vitro culture conditions, where the concentrations of glucose and glutamine are significantly higher than physiological, whereas other components are quite often missing
3.2 Therapeutic potential in obesity Although the incretin effects of GIPR undoubtedly play a crucial role in preventing postprandial glucose excursion, there is still intensive debate on whether the GIPR should be activated or inhibited for the treatment of obesity
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