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Prescription medications such as Tirzepatide and Semaglutide have established safety data when used under medical supervision
10.1126/science.aat9528 135 KottakisF.NicolayB
This has been possible thanks to a new antibody test developed by pharmaceutical company Eli Lilly, with whom the team is collaborating, which allows them to measure tiny amounts of INSL5
It is abundant in secretory cells of the intestine and pancreas, co-existing with pancreatic polypeptide
The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]
