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This stress-induced ubiquitination did not reflect nonspecific degradation of damaged proteins but rather a regulatory process involving stress granule disassembly and reactivation of cellular homeostasis after stress removal [42]
Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]
(DOC 41 kb) Rights and permissions About this article Cite this article Weydert, C., Cullen, J
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