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Next, the glutamate molecules bind to specific message-receiving receptors on the next nerve cell

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Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD-9604 (Group 3), and 0.25 mg AOD-9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection