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So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER
Repair process impairment by pseudomonas aeruginosa in epithelial tissues: major features and potential therapeutic avenues
As medicine continues to evolve, embracing technology and comprehensive care models will be key to addressing complex health challenges
doi: 10.1016/j.neubiorev.2015.11.005 66 MooreK.MadularuD.IriahS.YeeJ
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