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MSKCC and Columbia University jointly hold patents on hydroxamic acid-based polar compounds, including vorinostat (SAHA), that were exclusively licensed to Aton Pharma Inc., a biotechnology company that was acquired by Merck Inc

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Advanced analytical procedures including LCMS screening, heavy metal analysis, endotoxin testing, and sterility verification are routinely performed across commonly studied compounds

These are the kinds of considerations that make the initial water volume choice so important