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Melanotan-2 has no withdrawal or rebound effect, so skipping a dose does not reset tolerance or require re-titration
These earlier agents still appear on the list and remain options where cost, formulary placement, or tolerability favour them, though the trials show smaller average effects than semaglutide or tirzepatide
Image Credit: Drazen Zigic/Istockphoto.Why Doesn't Insurance Cover Semaglutide for Weight Loss
GLP-1 therapy, when appropriate, can be a helpful tool, but it is never used alone
One, patients may be new to GLP-1 medications and are slowly adjusting or they may be on too high of a dose too fast
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