This is especially concerning for people with conditions like heart failure or liver disease, in which fluid balance is important
Unlike other peptides in its class, Ipamorelin is highly selective, focusing almost exclusively on growth hormone release without affecting other hormones like cortisol or prolactin
For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period
Non-Scale Wins: Notice improvements in energy, how clothes fit, or reduced joint pain these changes matter too
Zhang N, Tao J, Gao L, Bi Y, Li P, Wang H, et al