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That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route
Researchers are examining whether altered NNMT activity affects nicotinamide metabolism, NAD-related pathways, methyl-donor balance and selected metabolic processes
No dose-ranging study has established a human oral dose for this compound, so the high oral numbers circulate as community and vendor convention rather than as published clinical figures
Dosing above 120mg/day shows no additional enzyme inhibition benefit but significantly increases peptide consumption cost
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