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Setria plays a key role in protecting all kinds of cells from the damaging effects of ingested chemicals and potential carcinogens the body has already absorbed
It functions as an electron donor in redox reactions, cycling between its reduced (GSH) and oxidized (oxidized glutathione) states to mitigate oxidative stress
This led to Compound 13 (DNS-0056), a nanomolar (IC 50 : 26 nM), orally bioavailable (90%), and brain-penetrating (maximum brain plasma ratio: 1.7) PDE1B inhibitor with good memory-enhancing effects in the rat NOR test
Absorbance measurements for all assays were recorded using a multifunctional microplate reader (Tecan, Switzerland)
Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, et al
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