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A 2025 systematic review of the compound identified only 36 total studies, 35 of which were conducted on animals and just one single study (with a sample size of 12!) conducted on humans
1 , 2 Constipation is reported in 4% to 12% of patients and occurs more frequently in individuals with obesity, likely due to the use of higher doses
Some are trends
Open 7 , e2425614 (2024)
Network meta-analyses confirm Retatrutides edge in total weight loss but highlight Tirzepatides superior profile for glycemic control, insulin resistance reversal, and systemic health benefits
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