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Figure 2 5 Clinical research progress and safety evaluation 5.1 Clinical efficacy studies Tirzepatide, a novel dual GLP-1 and GIP receptor agonist, has demonstrated remarkable efficacy in the management of type 2 diabetes and obesity, as evidenced by multiple high-quality clinical trials (43, 44)
demonstrated that human physiological concentrations of UA modulate the activity of SOD1 and SOD3 by preventing their inactivation by hydrogen peroxide (H 2 O 2 ) [37]
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Detailed views of boxed regions show that W297 and R299 in the active GLP-1R structure adopt similar orientations compared to the equivalent residues in CRF 1 R
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