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Overcoming drug resistance by taking advantage of physical principles: pressurized intraperitoneal aerosol chemotherapy (PIPAC)

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We used interpolated growth curve fitting to calculate the tumor load in the treated mice when control mice reached 50% tumor load (on average, 14.8 days after treatment initiation)

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172 Natural compounds such as curcumin, quercetin, and salvianolic acid B have also demonstrated transporter-inhibitory properties with relatively low toxicity, although issues with solubility and bioavailability have limited their clinical utility and prompted formulation optimization