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IGF-1 LR3 takes a more direct approach, focusing on cell regeneration and repair
When oxygen availability is limited, glucose is the most metabolically efficient fuel, and during myocardial ischemia, the ratio of acetyl-CoA/CoA in mitochondria increases, leading to the activation of pyruvate dehydrogenase (PDH) kinase, which in turn phosphorylates PDH to inhibit its activity
Damera G, Fogle H, et al
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doi: 10.3906/vet-0805-11 Zeyner A, Harmeyer J
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