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The review cautions that effective dosing, duration, and efficacy for non-metabolic and neuropsychiatric indications, including Alzheimers disease and substance use disorders, remain to be established

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While weight loss was more pronounced with semaglutide, we were unable to demonstrate a significant difference with metformin

Beyond their metabolic benefits, GLP-1 RAs exhibit neuroprotective and psychotropic effects, potentially benefiting mental health conditions like depression and anxiety