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As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (, , , , , ) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (, )

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Bibcode:2009PNAS..106.9109M

DOI: 10.1016/j.tips.2016.06.007 52

A strict calorie program is required (VLCD) during the program and you shall prepare yourself with recipes and guides