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Insurance coverage will be a challenge if not expanded to include other conditions, one physician said, so FDA approval is paramount. This challenge echoes concerns of patients, who also list high costs as the primary obstacle to GLP-1RA treatment, according to The Cure GLP-1RA Report: Insights from Patients on GLP-1RA Medications and the Future of Obesity Treatment, which reports results of a survey of patients who had taken GLP-1RA medications
Arch Gen Psychiat 52: 805818
GLP-1 also regulates the growth of the Islets of Langerhans and enhances beta cell proliferation and it supports the health of the cells so they have an improved, longer and healthier life span
The caveat is uniform and important: a mechanistic effect observed in a rat gastric cell assay does not prove the same effect will occur in a human tendon after nasal inhalation
The SURPASS trials showed A1c reductions of 1.24% to 2.58% depending on the dose and comparator
