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The effective blood-brain barrier mechanism impeding the transport of monoamines has been attributed to both the presence of tight junctions cementing adjacent endothelial cells of the cerebral capillary walls, along with high concentrations of dopa decarboxylase and monoamine oxidase (MAO) in the cerebral capillary endothelium (Bertler et al, 1966
Thus, proteostasis failure is often a network phenomenon: a primary bottleneck in one organelle can propagate into secondary collapse elsewhere
This is crucial for anyone with conditions that impair nutrient absorption from food or pills
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