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But after clinical trails showed its promising effects on weight loss, in 2021, the FDA approved semaglutide (Wegovy), a once-weekly injection, for weight loss in adults when used in combination with a healthy diet and routine exercise

It also has a growing research base, with work looking at how engaging these three pathways together shapes metabolic and insulin signaling (Coskun et al., 2022, Cell Metabolism)

Users can expect an average weight reduction of about 15%, with more than 80% of users experiencing significant decreases after just 12 months

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